Schnitzler syndrome

Content last updated on: January 18, 2015


Summary of Schnitzler syndrome

Schnitzler syndrome is a disease characterized by urticarial skin rash, fever and joint and bone pain. A so-called paraprotein is found in the blood of patients. Schnitzler syndrome is a very rare disease that presents predominantly in patients over 50 years of age. The cause of the disease is unknown. Treatment with anti-inflammatory drugs such as anakinra is effective.


Skin rash, fever and bone pain are symptoms of Schnitzler syndrome

Schnitzler syndrome is characterized by several symptoms. In some patients they present all at the same time, but in most cases the disease starts with one or two symptoms. Later in the course of the disease, months or years later, new symptoms may appear. Symptoms of Schnitzler syndrome are:

- skin rash: chronic and recurrent urticaria are the presenting symptom in most patients with Schnitzler syndrome. At first the rash is non-itching, but that may change over time. The rash can affect all parts of the body, but spares the palms of the hands, soles of the feet, head and neck in most patients.

Read more »