Summery of HIDS
HIDS is an abbreviation of Hyperimmunoglobulin D and periodic fever syndrome. It is a rare disease characterized by recurrent episodes (attacks) of spiking fever and other signs and symptoms of inflammation, such as enlarged lymph nodes, fatigue, headache, muscle pain and abdominal pain. These attacks last several days, after which patients recover spontaneously. Blood levels of immunoglobulin D are increased in HIDS patients. HIDS is a hereditary diseasese that can be proven by DNA-analysis.
The discovery of HIDS
HIDS was discovered in Nijmegen, The Netherlands in 1984 by professor J. van der Meer and his collegues. They found increased immunoglobulin D levels in blood of several patients with unexplained febrile attacks. They called it Hyperimmunoglobulin D and periodic fever syndrome. Hyper- is a Greek word, it means too much. To make things easier, the long name was abbreviated to HIDS.
Immunoglobulin D (IgD) is a protein that is produced by certain white blood cells. Several other immunoglobulins are known: IgG, IgA and IgM. These latter immunoglobulins play an important role in the adaptive immune system. They are able to recognize bacteria and virusses and initiate immune responses. The function of IgD is unknown. It is also ... Read more »