Content last updated on: January 18, 2015


Summary of CAPS

CAPS is an abbrevation of Cryopyrin-Associated Periodic Syndrome. It is a rare disease with a variable clinical picture. Symptoms are fever, joint pain, mucle pain, skin rash (especially urticaria), hearing loss, red eyes or meningitis. It can range from mild to very severe. Symptoms appear episodical or can be continuous. CAPS is a hereditary disease. It can be treated with anti-inflammatory drugs such as anakinra or canakinumab.


CAPS is also called FCA, MWS, or NOMID

The cryopyrin-associated periodic syndrome (CAPS) was named in 2001, when it was found out that three diseases that until then were thought to be unrelated share the same cause:

- Familial cold autoinflammatory syndrome (FCAS)

- Muckle Wells syndrome (MWS)

- Neonatal onset multisystem inflammatory disease (NOMID), which is also known as chronic infantile neurologic, cutaneous and articular (CINCA) syndrome.

The names CAPS, FCAS, MWS, NOMID and CINCA are still used by some for to discribe this disease, which can be confusing.


CAPS has variable symptoms

Common symptoms of CAPS are:

- skin rash with non-itching urticaria

- fever

- red eyes

- joint or muscle pain

- fatigue

- hearing loss

- swelling of cartilage tissues, especially ... Read more »