Besides colchicine, anakinra and canakinumab, there are other drugs that can be prescribed to patients with an autoinflammatory disease. Here they are listed in alphabetical order.
What are they?
Corticosteroids are strong anti-inflammatory drugs. They are chemical derivated of the hormone cortisol, which is produced by the adrenal glands. Corticosteroids can be prescribes as tablets or given as an injection. Examples of corticosteroids are prednisone, dexamethasone and methylprednisolone.
Many patients with an autoinflammatory disease are prescribed a corticosteroid somewhere in the disease's course. In many cases, they are ineffective. High dose corticosteroids can be effecive in TRAPS, Adult onset Still's disease and Schnitzler syndrome.
In autoinflammation corticosteroids are only effective in high dose, such as prednisone 20mg per day or higher.
Corticosteroids have many side effects, especially when high doses are used for a long time. Frequently seen side effects of corticosteroids are:
- weight gain
- muscle weakness
- diabetes mellitus
- skin atrophy with easy bruising
- striae (purple stripes on the upper arms, abdomen or thighs)
- change in physical appearance (full face, fat accumulation on the abdomen and thin arms and legs).
- edema or fluid retention
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